2. Signaling Pathways
  3. Vitamin D Related/Nuclear Receptor
  4. Thyroid Hormone Receptor

Thyroid Hormone Receptor

THR

Thyroid Hormone Receptor

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Thyroid hormone receptor is a member of the nuclear receptor superfamily that shuttles between the cytosol and nucleus. Thyroid hormone receptors are ligand-dependent transcription factors that mediate the biological activities of thyroid hormone (T3). Thyroid hormone receptors are encoded by two genes, one for TRα and another for TRβ, which encode the major isoforms of TR, including TRα1, TRα2, TRβ1, and TRβ2. The thyroid hormone receptors mediate the pleiotropic activities of the thyroid hormone (T3) in growth, development, and differentiation and in maintaining metabolic homeostasis.

Thyroid hormone receptors are zinc finger transcription factors in the erbA superfamily that bind DNA at specific response element sequences (thyroid hormone response elements, TREs) and activate gene expression in response to thyroid hormone (T3). Thyroid hormone receptors have been shown to bind DNA as monomers, homodimers, or heterodimers with another erbA superfamily member, the retinoid X receptor (RXR).

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-111442
    GC 14
    		Antagonist
    GC 14 is a selective thyroid hormone receptor antagonist, with IC50 values of 35 nM and 200 nM for hTRβ and hTRα, respectively.
    GC 14
  • HY-12753AS
    Debutyldronedarone-d7 hydrochloride
    		Inhibitor
    Debutyldronedarone-d7 hydrochloride is deuterated labeled Debutyldronedarone hydrochloride (HY-12753A). Debutyldronedarone (SR35021) hydrochloride, the main metabolite of Dronedarone, is a selective thyroid hormone receptor α1 (TRα1) inhibitor. Debutyldronedarone hydrochloride inhibits T3 binding to TRα1 and TRβ1 by 77% and 25%, respectively. Debutyldronedarone hydrochloride can be used for the research of arrhythmic.
    Debutyldronedarone-d<sub>7</sub> hydrochloride
  • HY-P1252A
    Parathyroid Hormone (1-34), bovine TFA
    		Agonist
    Parathyroid Hormone (1-34), bovine TFA is a potent parathyroid hormone (PTH) receptor agonist. Parathyroid Hormone (1-34), bovine increases calcium and inorganic phosphate levels in vivo. Parathyroid Hormone (1-34), bovine can be used for th reseach of osteoporosis.
    Parathyroid Hormone (1-34), bovine TFA
  • HY-149218
    THR-β agonist 6
    		Agonist
    THR-β agonist 6 is an orally active, selective thyroid hormone receptor β (THR-β) agonist with EC50s of 0.03 μM and 0.22 μM for THR-β and THR-α, respectively. THR-β agonist 6 exhibits an xcellent liver-to-serum ratio of 93:1 in mice. THR-β agonist 6 has the potential for nonalcoholic steatohepatitis (NASH) research.
    THR-β agonist 6
  • HY-P4690
    pTH (13-34) (human)
    pTH (13-34) (human) is apTH ((Human parathyroid hormone) fragment.
    pTH (13-34) (human)
  • HY-162999
    TRIP13-IN-1
    		Inhibitor
    TRIP13-IN-1 (compound 20) is a potent ligand and inhibitor of TRIP13, demonstrating anti-cancer effects both in vitro and in vivo.
    TRIP13-IN-1
  • HY-P0059A
    Teriparatide acetate hydrate
    		Agonist
    Teriparatide acetate hydrate (Human parathyroid hormone-(1-34) acetate hydrate) is a PTH1 receptor agonist. Teriparatide acetate hydrate (Human parathyroid hormone-(1-34) acetate hydrate) can be used for osteoporosis research.
    Teriparatide acetate hydrate
  • HY-178015
    THR-β agonist 11
    		Agonist
    THR-β agonist 11 is an orally active and selective thyroid hormone receptor (THR-β) agonist. THR-β agonist 11 shows potent cholesterol-lowering activity in cholesterol-fed rats. THR-β agonist 11 significantly reduces serum total TG, LDL-cholesterol, liver total TC and TG levels, and alleviates hepatic steatosis, inflammation and fibrosis in HFD-CCl4-induced Metabolic dysfunction-associated steatohepatitis (MASH) model mice. THR-β agonist 11 can be used for the study of metabolic dysfunction-associated steatohepatitis (MASH) and other fibrotic diseases.
    THR-β agonist 11
  • HY-P4818
    Human PTH-(1-31) amide
    Human PTH-(1-31) amide is a PTH analog. Human PTH-(1-31) amide stimulate phosphatidylcholine hydrolysis and stimulates adenylyl cyclase release.
    Human PTH-(1-31) amide
  • HY-115434
    3,5-Diiodothyroacetic acid
    3,5-Diiodothyroacetic acid is a thyroid hormone analog. 3,5-Diiodothyroacetic acid lowers blood cholesterol concentrations. 3,5-Diiodothyroacetic acid can be used for hypothyroidism diseases research.
    3,5-Diiodothyroacetic acid
  • HY-171013
    THR-β agonist 8
    		Agonist
    THR-β agonist 8 (Compound 1) is an orally active agonist of TRα and TRβ. THR-β agonist 8 is promising for research of thyroid hormone-related diseases.
    THR-β agonist 8
  • HY-P3969
    Prepro-TRH-(160-169)
    		Agonist
    Prepro-TRH-(160-169) is one of the connecting peptides of thyrotropin-releasing hormone prohormone (pro-TRH), potentiates TRH-induced thyrotropin (TSH) release.
    Prepro-TRH-(160-169)
  • HY-19154
    Montirelin
    Montirelin (NS 3) is an analog of thyrotropin-releasing hormone (TRH), and exhibits high affinity to TRH receptors. Montirelin exhibits potent effects to central nervous system (CNS).
    Montirelin
  • HY-P4857
    pTH-Related Protein (7-34) amide (human, mouse, rat)
    pTH-Related Protein (7-34) amide (human, mouse, rat) is a potent antagonist of parathyroid hormone (PTH).
    pTH-Related Protein (7-34) amide (human, mouse, rat)
  • HY-111983
    Etiroxate
    		Agonist
    Etiroxate (CG-635) is a lipid lowing compound which can be used for hyperlipoproteinemia research.
    Etiroxate
  • HY-143613A
    THR-β agonist 2 diacetate
    		Agonist
    THR-β agonist 2 (Compound 3) diacetate is a selective thyroid hormone receptor β (THRβ) agonist with an EC50 of 1.42 μM. THR-β agonist 2 diacetate can regulate the biological pathways mediated by thyroid hormones. THR-β agonist 2 diacetate can be used for the study of metabolic diseases.
    THR-β agonist 2 diacetate
  • HY-182688
    ITYR-DBRMD
    ITYR-DBRMD is a type III deiodinase (DIO3) inhibitor. ITYR-DBRMD shows antidepressant-like activity and reduces latency to feed in mice. ITYR-DBRMD can be used for the research of depression.
    ITYR-DBRMD
  • HY-175676
    THR-β agonist 10
    		Agonist
    THR-β agonist 10 is an orally active and selective THR-β agonist, with an EC50 of 11 nM. THR-β agonist 10 significantly reduces ALT (Alanine Aminotransferase), TC (Total Cholesterol), and LDL-C (Low-Density Lipoprotein Cholesterol) levels, and improves steatosis, ballooning, inflammation and fibrosis in the metabolic dysfunction-associated steatohepatitis (MASH) mouse model. THR-β agonist 10 can be used for the study of MASH.
    THR-β agonist 10
  • HY-147500
    TRβ agonist 2
    		Agonist
    TRβ agonist 2 (Compound 1) is a potent agonist of TRβ. TRβ agonist 2 reduces lipid accumulation in HepG2 and promote lipolysis with comparable effects. TRβ agonist 2 is a new potential TRβ-selective thyromimetics.
    TRβ agonist 2
  • HY-18341BR
    L-Thyroxine sodium (Standard)
    L-Thyroxine (sodium) (Standard) is the analytical standard of L-Thyroxine (sodium). This product is intended for research and analytical applications. L-Thyroxine sodium (Levothyroxine sodium) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4).
    L-Thyroxine sodium (Standard)
Cat. No. Product Name / Synonyms Application Reactivity